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Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping.
Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr. Loh ED, et al. Cytogenet Cell Genet. 2000;89(1-2):2-5. doi: 10.1159/000015576. Cytogenet Cell Genet. 2000. PMID: 10894923
We report the chromosomal localization in both mouse and human of a novel G-protein-coupled receptor, GPR48, which resembles glycoprotein hormone receptors, that may be implicated in Wilms tumor deletion syndromes such as WAGR. ...Additionally, we show that Gpr48 an …
We report the chromosomal localization in both mouse and human of a novel G-protein-coupled receptor, GPR48, which resembles glycopro …
Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors.
Khan MZ, He L. Khan MZ, et al. Psychopharmacology (Berl). 2017 Apr;234(8):1181-1207. doi: 10.1007/s00213-017-4586-9. Epub 2017 Mar 13. Psychopharmacology (Berl). 2017. PMID: 28289782 Review.
Advances in various methods and techniques to investigate orphan receptors including in situ hybridization and knockdown/knockout (KD/KO) showed extensive expression of these receptors in the mammalian brain and unmasked their physiological and neuropathological roles. ... …
Advances in various methods and techniques to investigate orphan receptors including in situ hybridization and knockdown/knockout (KD/KO) sh …
Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor.
Loh ED, Broussard SR, Kolakowski LF. Loh ED, et al. Biochem Biophys Res Commun. 2001 Apr 6;282(3):757-64. doi: 10.1006/bbrc.2001.4625. Biochem Biophys Res Commun. 2001. PMID: 11401528
The genomic structure of GPR48 has several features in common with genes in the glycoprotein hormone receptor family. ...The complete gene spans more than 60 kb with 18 exons and 17 introns. Northern blot analysis demonstrated high expression of GPR48 in the adult h …
The genomic structure of GPR48 has several features in common with genes in the glycoprotein hormone receptor family. ...The complete …
Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapses.
Guan X, Duan Y, Zeng Q, Pan H, Qian Y, Li D, Cao X, Liu M. Guan X, et al. J Biol Chem. 2014 Sep 19;289(38):26492-26504. doi: 10.1074/jbc.M114.564138. Epub 2014 Jul 25. J Biol Chem. 2014. PMID: 25063812 Free PMC article.
Here, we report that leucine-rich G protein-coupled receptor 4 (Lgr4/Gpr48) is highly expressed in Purkinje cells (PCs) in the cerebellum. ...
Here, we report that leucine-rich G protein-coupled receptor 4 (Lgr4/Gpr48) is highly expressed in Purkinje cells (PCs) in the cerebe …